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Abstract

FLUORIDE EFFECT ON MINIMUM INHIBITORY CONCENTRATION AND GROWTH DYNAMICS OF LACTOBACILLUS ACIDOPHILUS AND LACTOBACILLUS SALIVARIUS

Sandhya Priya Parthasaradhi and Jasti Pramoda Kumari*

ABSTRACT

Fluoride is the simplest fluorine anion. Fluoride is required for the human beings to prevent early dental disorders and to meet body‟s minimum Fluoride levels. It is supplied to human beings through several sources such as water, food, green tea, tooth paste, mouth varnishes and gels etc. Of all the mentioned sources, drinking water is a major source of Sodium fluoride. Fluoride is added to the drinking water supplies by a process known as “Water fluoridation”. Sodium fluoride is a common agent used in water fluoridation. When drinking water, Fluoride concentration exceeds required levels in the body, Fluoride commence bacteriostatic activity against beneficial flora in the gastrointestinal tract. Two such commonly effected organisms are L.acidophilus and L.salivarius. These are probiotic organisms that help to maintain immunogenic gut against several pathogenic organisms. Hence, Minimum inhibitory concentration (MIC) and growth dynamics were assessed on L.acidophilus and L.salivarius in the presence of different Sodium fluoride concentrations. During the course of research, L.acidophilus and L.salivarius were observed to be inhibited at 20 mM and 40 mM Sodium fluoride concentrations respectively. At the same concentrations, growth densities of both the probiotic organisms were significantly reduced. The performed research evaluated growth dynamics of organisms in the media supplemented with Sodium fluoride. Addition of Sodium fluoride to the media exerted significance not only on the MIC and growth dynamics but also on the other metabolic activities of the organism uncertainly.

Keywords: Probiotics, Sodium fluoride, Lactobacillus acidophilus, Lactobacillus salivarius.


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