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Dr. Y. Thangam*, C. Shiranjivi and C. Govindasamy


The term ‗‗bacteriocin‘‘ was coined by Jacob in 1953. These molecules are defined as ribosomally synthesized anti-microbial peptides, proteins or proteinaceous complexes produced by bacteria that act mainly against closely related species. They were originally defined as proteins characterized by lethal biosynthesis, predominantly intra-species killing activity and adsorption to specific receptors on the surface of bacteriocins sensitive cells. Bacteriocin production is widespread among bacteria. It has been suggested that the majority of bacterial species synthesize bacteriocins. The mechanism of inhibition of pathogenic bacteria for several of those probiotic microorganisms is mediated by the production of bacteriocins. The application of bacteriocins such as colicins in livestock has been largely achieved by feeding bacteriocin-producing strains.

Keywords: Pseudomonas aeruginosa, bacteriocin, microcins and colicins, Gram negative and positive bacteria.

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