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K. S. Lavhate*, Prof. K. J. Kore and Prof. R. V. Shete


Microsphere are characteristically free flowing powder consisting of proteins or synthetic polymer having particle size ranging from 1μm- 1000 μm. This is a carrier technology achieved by incorporating therapeutic agent into biodegradable polymer or proteins. Microsphere are multiparticulate drug delivery system have a wide range of applications because of controlled and sustained release, it’s reduced toxicity/ side effect and enhance efficacy of drug toward a targeted site. Oral modified- release multiple-unit dosage form have always been more effective than conventional dosage form. The targeted drug delivery system attempting concentration of drug in tissue of interest or reducing the relative concentration of drug in the remaining other tissue. So that in future microsphere will find the central place in novel drug delivery system, particularly in diseased cell sorting, diagnostic, safe, gene and genetic material. The present review gives focus on type of microsphere, material used, method of preparation or evaluation of microsphere.

Keywords: Microsphere, controlled release, novel drug delivery, type of microsphere, method of preparations, application.

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