Abstract

PROTECTIVE EFFECTS OF SOLANUM LYCOPERSICUM FRUIT EXTRACT ON LEAD INDUCED MICRONUCLEI IN BONE MARROW CELLS OF MICE

*K Rudrama Devi and K Dilip Reddy

ABSTRACT

In the present investigation the antimutagenic effect of Solanum
lucopercicum fruit extract has been evaluated against lead nitrate
induced genotoxicity. Single IP administration of Solanum
lycopercicum fruit extract at various doses i.e. 250, 500 and 1000 mg
/kg. When treated individually did not induce micronuclei in
polychromatic erythrocytes of mice. A single I P of 40mg/kg, of lead
nitrate induced significant increase in the percentage of micronuclei in
bone marrow cells of mice. However after co administration of three
doses of Solanum lycopercicum fruit extract there was a dose
dependent decrease in the % of micronuclei was observed. Thus the
results clearly indicate the preventive effects of Solanum lycopercicum fruit extract against
lead induced genotoxicity in bone marrow cells of mice. Therefore the data indicate that SL
fruit extract is a safer dietary component in cancer chemo preventive strategy.

Keywords: Solanum Lycopercicum fruit extract (SLFE), Lead Nitrate, Micronuclei.