FORMULATION AND EVALUATION OF PHYTOSOMAL NANOCARRIERS FOR ENHANCED CHRYSIN DELIVERY
Annamma Anthrayose* and Neema George
ABSTRACT
The present work was designed to improve solubility and
bioavailability of Chrysin by the development of Chrysin loaded
nanophytosomes by rotary evaporation method. The formulation of
phytosome evaluated for particle size ,zeta potential, SEM, FTIR,
DSC, entrapment efficiency, drug content, solubilty , in vitro drug
release and release kinetics. The particle size by DLS was found to be
in nano size range. The SEM, FTIR, DSC and solubility analysis
confirmed the formation of phytosome. Chrysin nanophytosome
showed better in vitro drug release when compared to Chrysin. The
kinetics of the drug release was found that it predominately follows
zero order and Higuchi kinetics with non fickian diffusion mechanism.
Keywords: Chrysin, flavanoid, nanocarrier, nanophytosome, rotary evaporation.
[Full Text Article]