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Shivakumar Hugar*, Shivapraksha S. M., Biradar S. S. and Shivakumar B.


Objective: The present study was designed to evaluate cardioprotective activity of seeds of Moringa oleifera against isoproterenol induced MI in Wistar albino rats. Materials and methods: In this study, at the end of 32nd day, after treatment, fasting blood samples used for the estimation of serum cardiac enzymes namely Lactate dehydrogenase (LDH), Creatine phosphokinase (CPK), Aspartate transaminase (AST), Alanine transaminase (ALT), Creatine phosphokinase-MB (CK-MB) and lipid profile namely Total cholesterol (TC), Triglyceride (TG), HDL and LDL. Further, rats were sacrificed for the removal of heart tissues for the estimation of myocardial marker enzymes (LDH, CPK, AST, ALT and CK-MB) and antioxidant enzymes namely GSH and LPO. Results: The results of preliminary phytochemical screening revealed the presence of flavonoids, tannins, glycosides and carbohydrates. Control group (Isoproterenol (85 mg/kg i.p.) animals exhibited significant altered levels of cardiac enzymes in serum and heart tissue and antioxidant enzymes of heart tissue. The extract of Moringa oleifera significantly reversed all the parameters of serum and heart tissue cardiac enzymes and antioxidant enzymes level heart tissue. Conclusion: The metanolic extract of Moringa oleifera seeds exhibited dose dependent significant cardioprotective activity by significantly attenuating the altered parameters of serum as well as heart tissue cardiac enzymes and tissue antioxidant enzymes of heart tissue in experimental animals. Thus the results of the present study suggest that seeds extract of the title plant possesses cardioprotective activity.

Keywords: Moringa oleifera, Isoproterenol, cardioprotective.

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