COMPARSION STUDIES ON TRANSDERMAL FILMS OF NATURAL TAMARIND SEED POLYSACCHARIDE EXTRACT CONTAINING ANTI HYPERTENSION DRUG WITH PVA ,HPMC AND GUAR GUM.
M.SantoshNaidu, G.V.Radha, P.Girish1and D.Lohithasu*
ABSTRACT
Objective of the study: The present study was to compare the
transdermal film property of the natural Tamarind seed polysaccharide
extract with the synthetic and natural polymers like PVA, HPMC and
Guar gum. The transdermal films prepared by solvent casting method
using Tamarind seed polysaccharide (TSP) alone and combinations
with other polymers and film properties are evaluated. The release
property of various film forming agent in increasing order are
TSP>PVA>guar gum>HPMC. Conclusion: Tamarind seed
polysaccharide (TSP) combination has showed the drug retardant
property. The order of drug release for different formulation is given as
follows F2>F1>F8>F7>F14>F11>F6>F5>F4>F3>F13>F12>F9>F10.
Formulated Transdermal Films evaluated for various physicochemical parameters and in vitro
permeation studies. Transdermal drug delivery system (TDDS) facilitates delivery of
therapeutically effective amount of drug across a patient’s skin with controlled rate.
Keywords: Tamarind seed polysaccharide (TSP), Retardant property, PVA, HPMC and Guar gum.
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