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*Merai Ankit H and Anil G Jadhav


Recently the world is turn to green/herbal pharmacy because the allopathic drug having major side effect. The main aim of present study was to evaluate the anti ulcer activity of Gymnema sylverstre. For the gastric ulcer there are varieties of drugs available but these drugs having major side effects. Bone structure alteration, iron deficiency anemia, risk of vitamin B12 deficiency may cause by Cimetidine, Famotidine, Ranitidine, Sucralfate drugs use in gastric ulcer. Cardiac problems may also cause by proton pump inhibitors. Anti ulcer activity study was studied using different leaves extract like pet-ether, chloroform, alcohol, aqueous of Gymnema Sylverstre on different models of gastric ulcer, such as acetic acid induced chronic gastric ulcer, pylorus ligation and stress induced ulcer models. The extracts administered orally with the dose of 200mg/kg. All the extracts increase the healing process of ulcer (P< 0.05). But alcoholic extract was more significant when it compare with standard (P<0.001). In the case of pylorus ligation and stress induce ulcer models alcoholic extract gave more significant anti ulcer activity (P< 0.001). So we concluded that alcoholic extract of Gymnema sylverstre possess significant anti ulcer activity.

Keywords: anti-ulcer, Gymnema sylverstre, acetic acid induce ulcer model, pylorus ligation, stress induce ulcer model.

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