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*Priya Bhatt, Dipti Patel, Rakesh Chaudhari

Department of Pharmaceutics, Baroda college of pharmacy, Limda, Vadodara, India.


In the present study, an attempt was made to develop multiple unit floating pulsatile beads of Lornoxicam by simple ionotropic gelation method intended for chronotherapy of rheumatoid arthritis. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by burst release. Sodium alginate was used as matrix forming polymer and NaHCO3 was used as floating agent. Drug loaded multiparticulates were subjected to various characterizations like Size measurement, flow properties study, % drug entrapment, floating study, swelling study and dissolution study. Final formulation containing 4% sodium alginate and NaHCO3: Sodium alginate ratio of 0.5:1 was optimized by 32 factorial design and response surface modeling. An optimized formulation provided expected two phase release pattern with initial lag time during floating in acidic medium followed by rapid pulse release in phosphate buffer. Stability studies of an optimized batch showed no significant change in drug entrapment efficiency, floating time, swelling index as well as drug release behavior after storage at 40 20C and 755% RH for one month. This approach suggested the use of calcium alginate floating beads as promising floating pulsatile drug delivery system for siteand time-specific release of drug acting as per chronotherapy of rheumatoid arthritis.

Keywords: Floating pulsatile beads, Ionotropic gelation, Lornoxicam, Chronotherapy, Rheumatoid arthritis.

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