FORMULATION AND EVALUATION OF FLOATING BEADS FOR CHRONOTROPIC DELIVERY OF LORNOXICAM
*Priya Bhatt, Dipti Patel, Rakesh Chaudhari
Department of Pharmaceutics, Baroda college of pharmacy, Limda, Vadodara, India.
ABSTRACT
In the present study, an attempt was made to develop multiple unit
floating pulsatile beads of Lornoxicam by simple ionotropic gelation
method intended for chronotherapy of rheumatoid arthritis. Floating
pulsatile concept was applied to increase the gastric residence of the
dosage form having lag phase followed by burst release. Sodium
alginate was used as matrix forming polymer and NaHCO3 was used
as floating agent. Drug loaded multiparticulates were subjected to
various characterizations like Size measurement, flow properties
study, % drug entrapment, floating study, swelling study and
dissolution study. Final formulation containing 4% sodium alginate
and NaHCO3: Sodium alginate ratio of 0.5:1 was optimized by 32
factorial design and response surface modeling. An optimized
formulation provided expected two phase release pattern with initial
lag time during floating in acidic medium followed by rapid pulse release in phosphate
buffer. Stability studies of an optimized batch showed no significant change in drug
entrapment efficiency, floating time, swelling index as well as drug release behavior after
storage at 40 ±20C and 75±5% RH for one month. This approach suggested the use of
calcium alginate floating beads as promising floating pulsatile drug delivery system for siteand
time-specific release of drug acting as per chronotherapy of rheumatoid arthritis.
Keywords: Floating pulsatile beads, Ionotropic gelation, Lornoxicam, Chronotherapy, Rheumatoid arthritis.
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