WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



*N. G. Raghavendra Rao1, Harsh Panchal2, Mohd Abdul Hadi3, B. Mahipal Reddy1

1Dept of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Karimnagar -AP, INDIA.
2Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga-Karnataka, INDIA.
3Dept of Pharmaceutics, Bhaskar Pharmacy College, Moinabad, R.R District, Hyderabad-A.P. INDIA.


Terbutaline sulphate is a β2-adrenergic agonist bronchodilator and used to treat bronchospasm (wheezing, shortness of breath) associated with lung diseases such as asthma, bronchitis, and emphysema. Terbutaline sulphate elimination half life 3 to 4 hrs (oral), thereby decreasing bioavailability up to 14.8%. So in order to improve the bioavailability and efficacy we have designed tablets-filled-capsule system. The system comprises of different doses of immediate release tablets (IRT) and sustained release tablets (SRT) contained in a HPMC capsule. The drugloaded core tablets were produced by wet granulation procedure using alcoholic solution of PVP K-30 as a binder. Different composition of IRT prepared with varying amount of sodium starch glycolate (as a superdisintegrant), and SRT was prepared with different ratios of ethyl cellulose to HPMC and number (5 of tablets in a HPMC capsule) were used to obtain different drug release rates. The prepared tablets were subjected for post-compression parameters. The compatibility of drug with other ingredients was checked by FTIR and DSC studies. FTIR and DSC results revealed that there was no interaction between dug and other excipients. All the pre and post-compressional parameter are evaluated were prescribed limits and results were within acceptable limits. The in-vitro performance of our best tablet-filled-capsule system showed the desired behavior, the drug contained in the IRT (immediate release tablets) dissolved within the first 45 min, whereas the drug contained in the sustained release tablets was released over a period of 10 to 12 hrs. Based on the release kinetic parameters calculated, it can be concluded that tablets containing HPMC and EC were particularly suitable approaching to sustain or prolong release over 10-12 hrs time periods. From this, study it can be concluded that, tablets-filled-capsule systems containing Terbutaline sulphate shows both sustained release as well as immediate release may improve the bioavailability and efficacy.

Keywords: Sustained release, terbutaline sulphate, tablets filled capsule system, immediate release tablet, hydroxy propyl methyl cellulose.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More