A COMPARATIVE STUDY OF ANTI INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF FENUGREEK (TRIGONELLA FOENUM GRAECUM) AND CARAWAY (CARUM CARVI) AQUEOUS AND OIL SEED EXTRACTS IN EXPERIMENTAL MODEL OF ULCERATIVE COLITIS
Mai Elsayed* and Rasha H. Hussein
ABSTRACT
Ulcerative colitis is a chronic inflammatory bowel disorder that
increase the risk of colon cancer. The usage of natural antioxidants
exhibit great interest as a means to avoid oxidative damage. This study
evaluated the effect of fenugreek and caraway either in form of
aqueous or oil seeds extracts on experimental model of ulcerative
colitis in rats. Colitis was induced using of 4% acetic acid solution.
Groups were: G1: healthy control group, G2: ulcerative colitis group,
G (3, 4) : ulcerative colitis supplemented with fenugreek aqueous and
oil extracts, respectively, G (5, 6) : ulcerative colitis supplemented
with caraway aqueous and oil extracts, respectively. Colon samples
were assayed for oxidative stress and inflammatory biomarkers along
with colon histology and DNA fragmentation. Results showed that treatment with fenugreek
and caraway either in form of aqueous extract or seed oil extracts protect against ulcerative
colitis effects as shown by improvement in antioxidant enzymes level and inflammatory
biomarkers, histological and genetical evaluation. These findings indicated that fenugreek
and caraway aqueous and oils extracts have defensive effects against acetic acid-induced
ulcerative colitis which might due to their anti-inflammatory, antiulcerative and antioxidant
properties. Therefore, they can possibly used for successful treatment of ulcerative colitis.
Keywords: Fenugreek - Caraway - Ulcerative colitis- DNA fragmentation -Antioxidant-Inflammation.
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