A REVIEW ON SOLID DISPERSION AND ITS APPLICATION
G. Y. Srawan Kumar*, G. Naveen, J. Anand Babu, K. Gopi Krishna, K. Gopi. D. Rama Brahma Reddy
ABSTRACT
The drugs have been classified into 4 categories by BCS classification
system. Based upon permeability and solubility parameters. In
formulation most of the drugs are poor solubility, due to this the
bioavailability of the drug In vivo conditions is less. To improve the
bioavailability of this type of drugs, the solubility is enhanced by
various approaches in this research work we approach solid dispersion
technology for improving the solubility of poorly soluble drugs and
adopted by various preparation methods. This formulation is used in
various drug delivery systems i.e. oral, tropical, parental, ocular,
etc.....These formulations can be used to verity of drugs such as
amorphous and crystalline substances. Recently, solid scale systems
have received much interest as a way to resolve solubility issues
because of their cost-effectiveness and technical simplicity compared
to liposome’s and other colloidal drug carriers. Solid dispersion have
proven to be a better alternative over other approaches currently available for improving
bioavailability of number of drugs with low solubility. Solid dispersion have been extensively
developed for a wide range of drugs and have been evaluated for in vitroand in vivo
applications by various routes. They have alsobeen used for drug targeting. In fact, the
number of products based onsolid dispersion in the market and under clinical study is higher
than that of othertechnology-based applications. A surprisingly large proportion of new drug
candidatesemerging from drug discovery programs are water insoluble, and therefore poorly
bioavailable, leading to abandoned development efforts. Solid dispersion is an effective way
of improving the dissolution rate of poorly water soluble drug and hence it's bio availability. The water soluble carrier used in preparation is solid dispersion enhance the dissolution rate of the poorly water soluble drug. The review article focus on the methods of preparation, advantage, dis-advantages,& characterization of the solid dispersion.
Keywords: Solid dispersion, type of solid dispersion, carrier, polymer, drug release, drug polymer interaction.
[Full Text Article]