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Abstract

PREPARATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF PERINDOPRIL ERBUMINE TABLETS

*Ch. N. V. S. Mastan Rao, Ch. Akhil Kumar Reddy, Ch. Venkata Pavan, Ch. Gopi, Ch. Siva Sumanth and D. Ram Brahma Reddy

ABSTRACT

Perindopril Erbumine Tablets contain the active substance perindopril erbumine which belongs to a group of medicines known as angiotensin converting enzyme (ACE) inhibitors. These work by making your blood vessels wider, which makes it easier for your heart to pump blood through them. Fast dissolving oral films are useful in patients such as paediatric, geriatric, bedridden or developmentally disabled who face difficulty in swallowing conventional tablets or capsules and liquid orals or syrups leading to ineffective therapy. The delivery system consists of a very thin oral strip, which is simply placed on the patient‘s tongue or any oral mucosal tissue, instantly wet by saliva the film rapidly hydrates and adheres onto the site of application. The present study was aimed to formulate fast dissolving oral films to enhance bioavailability and avoid pre systemic metabolism. The key is to develop successful oral film by solvent casting method and selected the right compatible excipients using FTIR studies. Oral film was fabricated using HPLC E5 and HEC polymer. The prepared films were evaluated for Organoleptic evaluations, film weight, thickness, folding endurance, tensile strength, drug content uniformity of films, surface pH, disintegration time and in-vitro dissolution studies. The formulation F5 has disintegration time of 7 seconds and is more promising and showed drug release of 98% after 5 minutes; hence formulation F5 was selected as best formulation.

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