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Abstract

DESIGN AND CHARACTERIZATION OF BUCCAL PATCHES OF CANDESARTAN CILEXETIL

Yella Thirupathi Reddy*, Rohit Saraswat and Reddy Sunil

ABSTRACT

Buccal route provides one of the potential routes for typically large, hydrophilic and unstable proteins, oligo nucleotides and polysaccharides as well as conventional small drug molecules. The oral cavity can be used for local and systemic therapy. Bucca patches of Candesartan Cilexetil was prepared by using polymers HPMC E-15, Sodium Alginate, Chitosan, Pectin, Eudragit RL-100, by employing solvent casting method. DCM: Methanol volume ratio, Glycerin & Propylene Glycol were selected as permeation enhancer and plasticizer. all the formulations prepare (F1-F16) were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content and Swelling study and all the results were found to be were found to be within the pharmacopeial limits, in-vitro drug release studies by using dialysis membrane. Among all the 16 formulations F4, F7, F11 and F16 formulation which contain HPMC E-15, Sodium Alginate, Chitosan, Pectin, Eudragit RL-100 had shown F4 formulation 91.96 ± 0.029, F7 formulation 87.94 ± 0.060, F11 formulation 82.45 ± 0.027 and F16 formulation 93.15 ± 0.038. Cumulative drug release within 6 hours. Drug excipient compatibility studies were carried out by using FTIR, DSC and it was observed that there were no interactions.

Keywords: Cumulative Drug Release, Buccal Patches, Candesartan Cilexetil.


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