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Yunita Dwi Tanti* and Erlina Maria Viva


Background: Epilepsy is still a major problem in pediatric neurology cases because epilepsy is a neurologic condition that related to social stigma, psychiatry comorbidities, and high cost. Antiepileptic treatment is a long term medication which often requiresa combination of some antiepileptic drugs (AED), so the adverse events of each AED need to be monitored. Recently, many clinicians concern about AED’s adverse event on Vitamin D deficiency. Vitamin D has many roles in the human body, particularly on calcium and bone metabolism. Results: One of the AED’s adverse events is affecting bone metabolism and potentially increase the risk of bone fracture. Based on WHO adverse drug reaction classification, this effect is included in type C category. Conclusion: Adverse drug events (ADE) is the main factor that contributes to the failure of the antiepileptic drug (AED) treatment.

Keywords: Epilepsy, Antiepileptic drugs (AED), Drug’s Adverse Effects, Bone.

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