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Gaurav Ramesh Chale* and Akshay Sarjerao Jeughale


In ancient era, drugs inducing unconsciousness, haemorrhoedal, vermicidal and purgative actions was inserted though rectal route in the form of suppository. In modern days most of the remedial medicines are prepared for rectal delivery to gain therapeutic blood concentration of the medicine and thereby enhancing the bio-availability. By inserting the drug through rectal route the pre-systemic effect in hepatic region and in GIT can be prohibited. Anal drug delivery systems, used as controlled release dosage form for treating the ailments like arthritis, increase blood pressure, asthma, AIDS and diabetes. Moreover, there is a rising interest that the suppositories can be used in the treatment of post operative pain and pain related with malignancy. Rectal drug delivery system is the area of enthusiasm for many researcher’s to evaluate consumption of drug from the rectal region for drug which are currently inserted through parental route. Viz., antibiotic and polypeptides The absorption of antibiotic and polypeptides is more effective from the small intestine than form the rectum and hence can be formulated using different absorption enhancers.[1]

Keywords: suppository, unconsciousness, pre-systemic effect, Rectal drug delivery system, absorption enhancers

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