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Abstract

FORMULATION AND EVALUATION OF NANOSPONGES LOADED HYDROGEL OF TIZANIDINE HYDROCHLORIDE

Gawali Chhaya Hiraman* and Junagade M. S.

ABSTRACT

Tizanidine hydrochloride, is centrally acting skeletal muscle relaxant. It undergoes first pass metabolism after oral administration which result in less bioavailability (40%). Tizanidine hydrochloride is mostly used in treatment of multiple sclerosis, back pain or certain injuries to the spine or CNS. The present study was carried out to formulate and evaluate Nanosponges loaded hydrogel of Tizanidine hydrochloride which will overcome of limitation of oral bioavailability. In the present research work nanosponges were prepared by hyper-cross linked β- cyclodexrin method by using diphenyl carbonate as cross-linker. Cyclodextrin based nanosponges are gain more consideration due to their improvement of solubility of poorly water soluble drugs. Four different formulations of hydrogels were prepared by using carbopol 934 with varying concentration of carbopol 934 and various evaluation studies were carried out. It was found that, nanosponges has potential modify drug release rate. The nanosponges loaded hydrogel has good drug release within 12 hours (96.33%), good stability, no irritancy.

Keywords: Tizanidine Hydrochloride, Nanosponges, Hydrogel.


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