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Abstract

UV SPECTROSCOPIC METHOD FOR ESTIMATION OF TOPIRAMATE BULK AND PHARMACEUTICAL DOSAGE FORMS

Sagar S. Yenare*, Dr. M. S. Tare, Payal S. Navasupe, Aniket B. Bangar and Sandesh S. Bole

ABSTRACT

The Current Study estimation of Drug Topiramate is Simple, Precise, Spectroscopic Techniques in Pharmaceutical Dosage Forms. The Standard Stock Solution Was Prepared For Topiramate by Weighing the Drug topiramate 100mg Topiramate in 100 ml methanol and make up volume of Volumetric Flask with methanol. The Stock was produce 1000μg/ml with methanol. The prepared Dilution were scanned at 235nm. The Specificity, Linearity, was in Range of 1-5μg/ml. The Correlation Coeifficient was found to be 0.999. That it will be said that equivalent. The Regession Equation are Found to be in Range of Y= 0.998X + 0.0259. The Spectroscopic Method are Should be Validated for Range, Linearity, Accuracy, LOD, LOQ, and Ruggedness, robustness,. The Limt of Detection and Limit of Quantitation of Topiramate was Found to be 0.015 (μg/ml) and 0.028 (μg/ml). The Recovery study involve that are said to be % recovery Topiramate was found to be an in range of 100.60 ±0.065 -100.40 ± 0.080. Discovered method can be greatly applied in Detemination of Topiramate in Pharmaceutical Dosage Forms.

Keywords: Topiramate, Method Validation, UV-Spectroscopy, ICH guidelines.


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