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Abstract

A PROSPECTIVE, FOLLOW UP STUDY TO ASSESS THE PLEIOTROPIC EFFECT OF TENELIGLIPTIN IN TYPE -2 DIABETES MELLITUS PATIENTS

*Kajal Singh, Dr. Ravikant, (M.B.B.S, M.D.) and Dr. Manisha Bisht, (M.B.B.S. M.D.)

ABSTRACT

Aims: Recently, beneficial pleiotropic effects with dipeptidyl peptidase-4 (DPP-4) inhibitors have been demonstrated in some studies. So this study was planned to investigate pleiotropic effect with recently approved Teneliglipitin in Indian population. The objective of our study was to find out the effect of teneligliptin as add on therapy on body weight, blood pressure, lipid profile, liver function test and renal function test. Methods: The study was a prospective follow up study conducted on type 2 diabetes mellitus patients. Forty patients having insufficient glycemic control with metformin and started on teneligliptin as add on therapy were enrolled for the study. The body weight, blood pressure, serum HBA1c, lipid profile, liver function test (GOT/GPT) and renal function test (Urea, Creatinine) were done at the baseline and follow up. Result: A total of 40 patients were enrolled for the study. Only 21 patients were available for follow up after 4 weeks and only one patient could be followed up after 8 weeks, so only 21 patients were included in the analysis at 4 weeks. The result of our study showed that there is pleotropic effect of teneligliptin on BP, body weight, lipid profile, liver function and renal function as seen with sitagliptin, though the results could not be proven statistically. Conclusion: This study concluded that teneligliptin has favourable effect on blood pressure, body weight, and renal function although the results were not statistically significant due to small sample size and short duration of study.

Keywords: Pleiotropic, Teneligliptin, Type II Diabetes mellitus.


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