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Abstract

ANTICANCER POTENTIAL OF A NOVEL SIDDHA METALLOMINERAL FORMULATION “KAALAMEGA NARAYANA CHENDHOORAM” AS MENTIONED IN “ATHMARAKSHA MIRTHAM ENNUM VAITHIYA SAARA SANGERAHAM” THROUGH A A549 CELL LINE STUDY FOR LUNG CANCER

Dr. R. Abinaya*, Dr. R. Vijaya Nirmala, Dr. R. Karolin Daisy Rani and Dr. M. D. Saravana Devi

ABSTRACT

Aim and Objective: The aim of the present study is to validate the Anti Lung cancer potentials of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a A549 cell line study. Methods: Cancer is a dangerous disease with increasing its prevalence day by day. There is no such medications which have a complete cure for cancer without any adverse effect. The super natural scientists gave a boon of siddha system of medicine which have the solutions for various diseases including Cancer without any adverse effect. Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham, a novel siddha metallo-mineral formulation which has a anticancer potential was underwent globally accepted technique for screening anticancer potentials through MTT assay for KMNC was done on A549 cell lines with various concentration of the drug as 6.25 μg/ml, 12.5 μg/ml, 25 μG/ml, 50 μg/ml, 100 μg/ml. Raising the modern medical science to support the effect of heavy metals usage in aspect of cancer treatment. Results: At the end of this preliminary research study, that the trail drug of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a A549 cell line study was found to be a potent anticancer medicine on human lung cancer cells. It showed (IC 50) 50% inhibitory concentration at 50μg/mL. There has been showed that there was a decrease in a number of cell with increasing the concentration of the drug as 6.25 μg/ml, 12.5 μg/ml, 25 μG/ml, 50 μg/ml, 100 μg/ml showed the percentage of viability as 93.73%, 83.56%, 61.28%, 40.95%, 23.96.% Thus the Further studies with the trail medicine KMNC will pave the right path towards the safe and potent as anticancer medicine. Conclusion: The present preliminary in-vitro study of a potent siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a A549 cell line study was found to be a potent anticancer medicine on human lung cancer cells.

Keywords: Kaalamega Narayana Chendhooram, KMNC, Chendhooram, Siddha, metallo-mineral formulation, A549 cell line, MTT assay, Lung cancer, Cancer.


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