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Abstract

IN VITRO EVALUATION OF THE ANTIBACTERIAL AND TRIPHYTOCHEMICAL POTENTIAL OF AN ORNAMENTAL AND MEDICINAL COMBRETACEAE AGAINST PSEUDOMONAS AERUGINOSA

Coulibaly Kiyinlma*, Kone Kéassemon Hervé Cédessia, Assi-Kaudjhis Chimène, Kouadio-Guessennd Nathalie and Zirihi Guede Noël

ABSTRACT

Infections caused by multidrug-resistant bacteria are among the most feared diseases in vulnerable individuals and immunocompromised people. In view of the limited number of antibiotics that are truly effective against these bacterial diseases, it is essential to find new drugs that are more active, broad-spectrum, less harmful and costeffective. The antibacterial properties of aqueous and ethanolic extracts 70% of the bark of the Terminalia mantaly trunk were tested on 16 strains, including 14 strains of Pseudomonas aeruginosa Ceftazidimeresistant from sick people and the environment, one strain ATCC 27853 and one strain Ceftazidime-sensitive by solid medium diffusion methods using blotting paper discs and microdilution in liquid medium on microplates, to determine the antibacterial parameters. The results show that the 70% ethanolic extract strongly inhibited all strains compared to reference Ceftazidime and aqueous extract, with minimum inhibitory concentrations ranging from <0.156 to 0.625 mg / mL, and bactericidal concentrations ranging from 0.156 to 1.25 mg/mL. The use of the classical method of phytochemical screening of medicinal plants has shown a richness in secondary metabolites, which provides scientific data to justify the therapeutic use of this plant in traditional medicine, particularly in the treatment of pathologies caused by these bacteria.

Keywords: Terminalia mantaly, Antibacterial potential; multi-resistant bacteria; Pasteur Institute; Côte d'Ivoire.


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