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Abstract

FORMULATION AND EVALUATION OF TELMISARTAN FLOATING DRUG DELIVERY SYSTEM

Bidkar S. J., Shelke M. M.*, Dama G. Y. and Bidkar J. S.

ABSTRACT

The present research work was an attempt to formulate and evaluate tablet containing Telmisartan in the form of tablet to prolong the release of orally administer. Telmisartan in the floating tablets by using different Grade of hydroxypropylmethylcellulose (HMPC). Citric acid, sodium bicarbonate as gas generating agent. Different viscosity grade polymer of HPMC k4 M, HPMCK100M were used a floating polymer. It was observed that different viscosity not only influence the drug release from hydrophilic matrix but they also affect the floating properties of tablets. Telmisartan is an anti-hypertensive drug under the class of angiotensin II receptor blocker. The bioavailability of Telmisartan is range between 42%-58%. Preformulation studies for drug excipient compatibility is done by FTIR spectroscopy it was observed that there was no compatibility problem with they are used in study. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and in-vitro drug release studies and the results were within the limits. The in vitro drug release studies were carried out in an USP type II apparatus in 0.1N HCL.

Keywords: Telmisartan HPMC K4M, HPMC K100M, gastric residence time, Floating tablets.


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