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Abstract

A DESCRIPTIVE REVIEW ON THE PHARMACOLOGICAL PROPERTIES OF HIGHLY SELECTIVE BETA BLOCKER ‘NEBIVOLOL’

Maira Iqbal, Afshan Siddiq*, Sadia Ghousia Baig and Qudsia Basri

ABSTRACT

This review focuses on “Nebivolol” a novel drug that has beta adrenergic blocking effect, especially the blockage of beta 1 receptor selectively so classified as third generation beta blocker. In this article the pharmacological effects of nebivolol are discussed along with its mechanism of lowering blood pressure in hypertensive patients and its vasodilator action in patients of erectile dysfunction. Nebivolol is also beneficial in reducing the mortality rate in cardiac patients as it prevents the target organ damage by neutralizing oxygen free radical. Nebivolol is rapidly absorbed and distributed well after being administered oral. Precaution is needed while using Nebivolol as it can result in severe allergic reactions in some patients.This article also explains the uniqueness of Nebivolol with respect to other beta blockers. Nebivolol is unique in its mechanism of producingvasodilatory effects by release of nitric oxide which is not associated with other beta blockers.

Keywords: Nebivolol, hypertension, erectile dysfunction, pharmacological effects, nitric oxide.


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