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Abstract

EMPLOYMENT OF PHOTORESPONSIVE POLYMERS IN DRUG DELIVERY AND THERANOSTICS TECHNIQUES

Chinara Zeynalova# and Huixia Lv*

ABSTRACT

Polymeric nanoparticles (NPs) as a novel drug delivery systems (DDS) possess so many advantages over typical carries, NPs retain into site of actions adequately with an extra specificity due to their passive (NPs retention through enhanced permeability retention (EPR) effect) and active targeting (Can attach one of ligands to binds special tissue molecules). Very recently, researchers have been more concerned about stimuli responsive; that achieved when Polymers attached to stimuli molecules as the Ultraviolet light (UV) responsive moiety Spiropyran (SP). SP modulate polymeric system to deliver load only when UV triggers SP structural changes lead to DDS release i.e. polymer-SP system would carry drugs intact especially in cancer therapy where premature release is truly an immense burden to overcome.

Keywords: Polymeric Nanoparticles, Solid Nanoparticles, Photoswitches, Spiropyran, Merocyanine, Photoresponse.


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