ROLE OF MMP1 AND MMP10 AS POTENTIAL MARKERS IN HEAD AND NECK SQAMOUS CELL CARCINOMA
Savita J. K., Varsha V. K., Girish H. C., Sanjay Murgod., C. Santosh Kumar and Mamatha N. S.
ABSTRACT
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases.
They are quite capable of degrading extracellular matrix and basement
membrane with subsequent invasion of malignant cells into the stroma,
intravasation into the blood or lymphatic circulation, and Formation of
metastases in distinct sites. Relevant to this review, the role of MMPs in
cancer biology is studied and documented relatively well and continues to
be the topic of intensive research. In addition to overexpressing several
MMPs in head and neck squamous cell carcinomas (HNSCCs),
expression has been associated with salient tumorigenic characteristics
such as cell proliferation, angiogenesis, invasion, and metastasis. This
review provides summary of MMP activities in general and particularly MMP1 & MMP10 in
cancers, and update of their activities in HNSCC.
Keywords: MMP1, MMP10, Head and Neck Cancers, Tumor Markers.
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