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Abstract

NOVEL STRATEGIES OF NAIL DRUG DELIVERY

Patel Jitesha, Parekh Hemangi, Patel Parth and Rajashree Mashru*

ABSTRACT

Nail disorders are produce discomfort in the performance of daily work, they disturb patients psychologically and affect their quality of life. The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Infections of foot and hand nails by fungi are a very common condition in millions of people. Such s infections may be difficult to treat, and currently prescribed oral antifungal medications may cause side effects ranging from skin rashes or liver damage. Other treatment modalities include the use of antifungal lacquers and topical medications. Use of chemical permeation enhancers has been a common approach for enhancing nail drug delivery. The potential of physical permeation enhancement techniques has been found to be higher than the potential of chemical permeation enhancers and macromolecular therapeutic agents. The techniques such as Iontophoresis, Ultra sound technique, Photodynamic therapy have been proven to improve transungual permeation. This article provides information regarding the nail anatomy, nail disorders, various method of treating nail disorder.

Keywords: Nail drug delivery, Nail disorder.


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