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Abstract

THE EFFICACY AND SAFETY ASSESSMENT OF TOPICAL CONTAINING EXTRACT OF PIPER NIGRAM AND DICTAMNUS DASYCARPU TURCZ FOR VITILIGO IN VIVO AND VITRO

Dr. R. Rachana Devendra*, Dr. Sheelpriya R. Walde and Dr. Ramteke Devendra S.

ABSTRACT

Vitiligo is the depigmentation disorder and recently it is also identified as a autoimmune disorder, in which antigens produced by melanocytes(including those released from damaged melanocytes) can be recognized by antigen-specific immune effecter cell including cytotoxic T-cell(CD8+), T-Helper cells(CD4+) and β-cells. The piperine from piper nigram linn. has shown a strong repigmentation capacity. The three phenolic glycoside from Dictamnus dasycarpu turz, has already been reported for it selectively show remarkable activity of inhibiting the proliferation of T-cells(CD8+). Both the drugs were separately use for the treatment of vitiligo, but never in a combination. The isolated phytoconstituents were formulated into o/w, PEG1000 and Bees wax type of cream and all the evaluation of cream were carried out; such as colour, pH, and viscosity, skin irritation in vitro and in vivo studies. All the evaluation parameters are found within limits and result found satisfactory. Formulation containing, combination of both the extracts have shown to be non irritant during draize skin irritation test and the drug release profile, invitro study shows the satisfactory result.

Keywords: Vitiligo, piper nigram Linn, Dictamnus dasycarpus turz, Topical cream.


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