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Abstract

GLIBENCLAMIDE LOADED FLOATING BEADS –INVITRO CHARECTERIZATION

M. Swetha*, Anjani Singh, Shiny Pauline A., P. Karthika and N. Jancy Laxmi Bai

ABSTRACT

The purpose of this investigation was to develop a controlled release floating drug delivery system (Floating beads) of Glibenclamide to improve the bio availability by gastric retention. The aim of the study was to develop and evaluate non-effervescent floating beads. Drugs having narrow absorption window and those which are absorbed mainly in stomach were developed as floating delivery system. FT- IR studies showed that there is no interaction between the drug and excipients. The beads were showed zero floating lag time and remained buoyant for more than 12 hr achieving the gastric retention properties.

Keywords: Glibenclamide, gastric retension, Floating beads, FTIR, Lag time.


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