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Abstract

FORMULATION AND EVALUATION OF LAMIVUDINE MICROPARTICULATED BIOADHESIVE VAGINAL TABLET FOR HIV FEMALE PATIENTS

T. Vijay Singh*, P. Shailendra, Dr. P. Arun, P. Bhavesh and D. Neelesh

ABSTRACT

The present study concerned with the formulation and evaluation of Microparticulated Bioadhesive Vaginal Tablet (MBVT). Lamivudine encapsulated microspheres were prepared by solvent evaporation method using ethyl cellulose as rate controlling polymer in different ratios. The microparticles were found to be discrete, spherical with free flowing properties and evaluated for particle size analysis, shape (scanning electron microscopy), flow properties, drug entrapment efficiency, and in vitro release performance. The selected microparticulated formulation that is microsphere formulation (EF3, containing drug: polymer ratio 1:4) was compressed in Tablet with a variety of bioadhesive polymers. The MBVTs were evaluated for weight variation, disintegration, hardness, friability, drug content, in vitro drug release, drug release kinetics, bioadhesion test, swelling index.

Keywords: Microparticulated Bioadhesive Vaginal Tablet, Lamivudine, Microparticles, Adhesive Micro Matrix System, Carboxy Methyl Cellulose, Methyl Cellulose, Bioadhesve Polymers.


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