EVALUATION OF ANTICANCER AND ANTIOXIDANT ACTIVITIES OF LEAF EXTRACT OF DESMODIUM TRIQUETRUM
Dr. Siju E. N.*, Deepika K. T., Rahul K., Dr. Hariraj N. and Minil M.
ABSTRACT
The Desmodium triquetrum (L.), (Tadehagi triquetrum), is a species of
flowering plant in the family Fabaceae. It belongs to the sub family
Faboideae. The antioxidant properties elicited by the extract may be
attributed to the presence of flavonoids. Flavonoids have been found to
possess antimutagenic and antimalignant effects. Moreover it has
protective effect against cancer by their effect on signal transduction in
cell proliferation and angiogenesis. Therefore the anticancer property
of D. triquetrum may be due to the presence of flavonoids. In vitro
antioxidant activity was evaluated by methods like reducing power
assay and DPPH assay. The extract showed good antioxidant activity
comparable to that of ascorbic acid. In vitro anticancer study of the methanolic extract of D.
triquetrum was evaluated by brine shrimp lethality assay, MTT assay, Alamar blue assay, and
Trypan blue assay in HeLa cells. The results indicated that the methanolic extract of D.
triquetrum possessed good anticancer property when compared to the standard drug 5-
Fluorouracil.
Keywords: Desmodium Triquetrum, Antioxidant and Antimalignant Effects.
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