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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHS OF ANTIEPILEPTIC DRUG

Dhananjay Kumar*, Sailesh Narayan and Shailendra Bindaiya

ABSTRACT

The objective of present study is to determine the permeation of Lamotrigine from transdermal patch into microcirculation of skin. Matrix type transdermal drug delivery system (TDDS) of Lamotrigine was prepared by the solvent evaporation technique. Several batches were prepared by using combination of HPMC (400, 425 and 450mg) and ethyl cellulose, Eudragit RSPO (50, 75 and 100 mg) in different ratios. Propylene glycol was used as plasticizer and as a permeation enhancer. Formulated transdermal patches were characterized for their physicochemical parameters like thickness, tensile strength, folding endurance, moisture content, moisture uptake and drug content uniformity. Patches were evaluated for their in-vitro drug release profile and ex-vivo skin permeation studies. Patches were also subjected to stability studies and skin irritation studies to determine their compatibility with skin. Result of evaluation studies revealed that Lamotrigine can be administered as a controlled drug delivery system to reduce frequency of drug administration. But this hypothesis requires further confirmation via in-vivo pharmacodynamic and pharmacokinetic studies in animal and human models.

Keywords: Lamotrigine, Transdermal, HPMC, EC, Eudragit, Eudragit, etc.


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