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Shravan Kumar Dholi*


Plants continue to serve as possible sources for new drugs and chemicals derived from various parts of plants. Scientific interest in medicinal plants has burgeoned in recent times due to increased efficiency of new plant-derived drugs and rising concerns about the side effects of conventional medicine.[1] Besides widespread use of botanicals as medicinal products in developing countries, such products are also becoming part of the integrative health care systems of industrialized nations known as ‚Äúcomplementary alternatives system of medicines‚ÄĚ (CAM). Safety and efficacy of natural herbal products is therefore a cause of concern to promote and rationalize their use.[2] Inflammation is a complex biological response of vascular tissues to harmful stimuli including pathogens, irritants, or damaged cells. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. The process of inflammation is necessary in healing of wounds. Acute inflammation is characterized by classical signs-edema, erythema, pain, heat, and above all, loss of function. Chronic inflammation results in a progressive shift in type of cells, present at site of inflammation. It is characterized by simultaneous destruction and healing of the injured tissue from incidence of inflammation. Acute models are designed to test drugs that modulate erythema, changes in vascular permeability, leukocyte migration and chemotaxis, phagocytosis-polymorphonuclear leukocytes and other phagocytic cells, measurement of local pain, antipyretic activity local analgesic action and rat paw edema. Chronic models are designed to find drugs that may modulate the disease process and these include sponge and pellet implants and granuloma pouches which deposit granulation tissue, adjuvant induced arthritis and rabbit mono-articular arthritis which have an immune etiology.[3]

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