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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF GLICLAZIDE USING 23 FULL FACTORIAL DESIGN

Upadhyay Vivek*, Bani Singh Kamal and Monika

ABSTRACT

The aim of the present study involved the formulation and evaluation of mucoadhesive buccal tablets of gliclazide, with objective of avoiding first pass metabolism and to with reduction in dosing frequency and provide prolonged release. Mucoadhesive buccal tablets of Gliclazide are prepared by direct compression method In this present investigational research work the mucoadhesive buccal tablets of gliclazide is prepared separately employing 23 randomized full factorial design by using xanthan gum, carbopol-934, HPMC-E15LV, In this experimental model, target is to determine how the t90% of drug release and mucoadhesive characters can be affected by adjusting three parameters, concentration of polymers xanthan gum, HPMC-E15LV, carbopol-934, of the mucoadhesive buccal tablets. 23 full factorial studies were designed to determine the interaction of three independent variables at two levels (low and high level concentration) The tablets were tested for weight variation, hardness, surface pH, drug content uniformity, swelling index, mucoadhesion strength and in-vitro drug release study.

Keywords: Mucoadhesive, First Pass Metabolism, Concentration, Gliclazide.


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