WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Shravan Kumar Dholi*, K. Thirupath and P. Kranthi Raju


Tecoma stans has been used medicinally throughout history by many different cultures. Many compounds have been found in the exudates of the Tecoma stans plant that have been used medically by humans and used as a defense mechanism by the plant. We have examined the pharma-cological anti-hyperlipidemic and hypoglycemic effectiveness of Tecoma stans in the obese fatty diabetic rat model. After treatment for 4 days Tecoma stans 250 mg/kg reduced triglyceride (34%), total cholesterol, (14%) and low density lipoprotein cholesterol levels (34%). These effects were dose-dependent and maintained for at least 5 weeks. Chronic treatment for 3-5 weeks also reduced post-prandial hypertriglyceridemia induced by olive oil 10 mg/kg in the fatty rats. A novel regulation by Tecoma stans of glucose levels was also observed in the fatty rat model. In a glucose tolerance test in obese and lean rats pretreatment with Tecoma stans 250 mg/kg demonstrated glucose levels were significantly less 2 hours post challenge (21%) in the Tecoma stans obese rats compared to the control group. Tecoma stans did not significantly reduce glucose levels at 120 min in the lean strain, in contrast to the 21% decrease seen in the obese rat. In vitro, Tecoma stans inhibited α-glucosidase activity (50% inhibition at 42.9), which compared to acarbose (50% at 53.8 μg/mL). The improvement in glucose tolerance at 120 min by Tecoma stans in obese fatty rats but not lean rats suggests that it may improve insulin receptor sensitivity and together with the significant reduction of hyper-triglyceridemia, cholesterol and low density liporprotein cholesterol suggests that Tecoma stans should be examined further by oral hypoglycemic / anti-hyperlipidemic therapy.

Keywords: Tecoma stans, anti-hyperlipidemic and hypoglycemic activity.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More