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Abstract

PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND IN VIVO ANTINEOPLASTIC PROPERTIES OF CARICA PAPAYA FRUITS

Md. Monirul Islam, Ariful Islam, Md. Wasim Bari, Dil Afroza, Mst. Zenika Nasrin, Md. Ismail Hossain, Md. Matiar Rahman and Mohammad Amirul Islam*

ABSTRACT

Oxidative stress, based on imbalance between pro-oxidants production and antioxidant defenses is involved in several human chronic diseases such as cancer, diabetes mellitus and coronary heart disease. This study sought to investigate the phytochemical profiles, antioxidant and in vivo antineoplastic properties of the Carica papaya fruits. Quantitative analysis demonstrated the total amount of polyphenols such as phenolics and flavonoids in several extracts. Four different in vitro methods were used to investigate the antioxidant activity. In in vivo anticancer assay, several methods were used to investigate cell growth inhibition. In DPPH and ABTS scavenging assays, methanol extract of C. papaya unripe fruits showed the highest antioxidant activity with the IC50 values of 81.83 μg/ml and 71.23 μg/ml respectively. In anticancer assay, result showed that methanol extract of C. papaya unripe fruits significantly (p<0.05 to p<0.01) decreased the viable cancer cell at the dose of 25 mg/kg and 50 mg/kg body weight respectively. The findings of the present study suggest that Carica papaya fruits may be a good source of pharmacologically important natural antioxidants and the methanol extract of C. papaya unripe fruits could have antiproliferative activity against EAC cell line and can be a potent source of anticancer agents to treat cancer.

Keywords: Phytochemicals, Antioxidants, ABTS, DPPH, cancer.


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