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Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM (PATCH)

Avinash Kumar Saroj*, Rizwana Khan and Bhawna Sharma

ABSTRACT

Transdermal drug delivery system (TDDS) are topically administered medicaments. Transdermal patches are pharmaceutical preparation of varying sizes, containing, one or more active ingredient, intended to be applied to the unbroken skin in order to deliver the active ingredient to the systemic circulation after passing through the skin barriers, and it avoid first pass effect. Transdermal patches delivers the drugs for systemic effects at a predetermined and controlled rate. Through a diffusion process, the drug enters the bloodstream directly though the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood, the drug will keep diffusing into the blood for a long period of time, maintaining the constant concentration of drug in the blood flow. Characterization of transdermal patch is use to check it’s quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity & cutaneous toxicological studies. The market for transdermal products has been in a significant upward trend that is likely to continue for the foreseeable future. An increasing number of TDDS products continue to deliver real therapeutic benefit to patients around the world. More than 35 TDDS products have now been approved for sale in the US, and approximately active ingredients are approved for use in transdermal drug delivery products globally.

Keywords: Transdermal patches, marketed TDDS, hydro propylene methyl cellulose, controlled release.


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