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Abstract

A BRIEF REVIEW ON MUCOADHESHIVE MICROSPHERES IN DRUG DELIVERY SYSTEM

Khushboo Shriwas* and Dr. Niranjan S. K.

ABSTRACT

The aim of this article is review the principles underlying the formulation and evaluation of mucoadhesive microspheres. There are many routes of mucoadhesive drug delivery system, oral route is the most ancient as well as preferred by patient being convent to take. Microspheres, noisomes, liposomes etc. Which modulates the release characteristics of the drug. Mucoadhesion has been a topic of interest in the design of novel drug delivery system to extend the residence time of the dosage form at the site of application or absorption and improve an intimate contact with the underlying absorption surface and enhance the bioavailability or therapeutic performance of drugs. The main advantage of this route for drug that are prone to their hepatic first pass metabolism. This review provides the brief knowledge about oral mucosal drug delivery by discussing briefly the structural features of mucosa, mechanism of bioadhesion, various theories of bioadhesion, general consideration in mucoadhesive polymer.

Keywords: Microspheres, mucoadhesion, mucoadhesive polymer, bioadhesion.


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