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Abstract

PRE-FORMULATION STUDY OF NANDROLONE DECANOATE FOR FORMULATION AS TRANSFEROSOMES FOR TDDS

Anand Kumar Malawat*, Priyanka Bhati and Mohsin Hasan

ABSTRACT

The first and foremost aim of the study was to prepare transferosomes which are recent approaches in modulating vesicle compositions. The second approach was to prepare a formulation of nandrolone decanoate in the form of transferesome which can be potentially useful for delivery of this drug and also overcome the binding affinity with the receptors. Transferosomal formulation of Nandrolone decanoate was prepared by using the lipid film hydration technique. For optimization of transfersome, different formulations (N1 to N6) were prepared using the various quantities of lipid & surfactant. The formulation (N3) was found with maximum entrapment efficiency. The shape and size of the optimized N3 formulation was confirmed through microscope and particle size and found that most of the particles were well identified. For Topical drug delivery of transfersomal gel of optimized N3 formulation was prepared by dispersing the formulation successfully in 1%, 1.5%, 2% carbopol 934. Formulation N9 (2% Carbopol 934) is optimized for further study. The % EE of optimized formulation (89.825 ± 0.100) with fruitful viscosity as well as spreadability. Apart from it, the particle size with polydispersity index of optimized formulation is 242.3nm with PDI 0.246. Optimized formulation in vitro drug release was studied in phosphate buffer (PB) pH 7.4 using Franz-type diffusion cells. To know precisely, the rate and mechanism of drug release, the in vitro data was fitted to zero order, first order, Higuchi and Korsmeyer-Peppas model. The results showed that the drug release of N9 formulation followed Korsmeyer-Peppas order which describes that the Nandrolone decanoate follows a controlled mechanism for release from transfersome. Thus, it can be concluded from the result obtained that the transferosomal gel formulation developed for transdermal delivery of Nandrolone decanoate possessed better skin permeation potential, and higher entrapment efficiency, as well as had ability as a self penetration enhancer.

Keywords: transferosomes, TDDS, nadrolone decanoate, skin permeation.


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