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Abstract

SCREENING OF THE STEM BARK OF MORINGA OLIEFERA FOR IT”S ANTIMICROBIAL AND WOUND HEALING ACTIVITY

Gunjan Sodhi*, Saumya Das and Avijit Mazumder

ABSTRACT

Moringa oleifera is a pan-tropical species that is known by such regional names as benzolive, drumstick tree, kelor, marango, nébéday, saijhan, and sajna. Over the past two centuries, many reports have appeared in scientific journals describing the nutritional and medicinal properties of it. Its utility as a non-food product has also been widely explained it is used as lumber, charcoal, water clarification, lubricating oil. Different parts of the plant contains essential minerals and are a good source of protein, vitamin, amino acids and various phenolic compounds.. It has more than 40 natural anti-oxidants. The leaves, pods, seeds, gums, barks and flowers of Moringa are used to relieve mineral and vitamin deficiencies, support a healthy cardiovascular system, promote normal blood-glucose levels, neutralize free radicals {thereby reducing malignancy}, provide excellent support of the body's anti-flammatory mechanisms, enrich anaemic blood and support immune system. It also improves eyesight, mental alertness and bone strength. It has potential benefit in malnutrition, general weakness, lactating mothers, menopause, depression. There is a need to explore therapeutic, nutritional and benefit of this gift of nature reported to be one of the world's most useful tree. The present work comprises of research work wound healing potential and anti-microbial activity of stem bark of Moringa oleifera. Wound healing activity was performed by Incision wound model and Excision wound model. In incision wound healing model, the tensile strength of the 2% and 5% test group and the povidone-iodine ointment treated group were compared to each other. Tensile strength of 5% exact ointment showed significant results and 2% extract ointment showed lesser but significant increase in tensile strength compared to the control group. Thus both concentrations of the extract as well as the standard drug showed a significant increase in tensile strength on the 14th day. In excision models the animals treated with the 5% w/w Moringa oliefera ointment shown to healed completely as compared to 2%w/w which was also at the complete healing stage as compared to control treated and the standard drug (povidone-iodine) treated group. The epithelization period of standard group and treated group was less in comparison with that of simple ointment base treated groups. The percentage of wound contraction was much more with the 5% w/w extract was similar to that of povidone-iodine treated group. 2%w/w treated group of animals showed significant wound contraction.

Keywords: Moringa, traditional uses, benefits, nutritional value, wound healing, therapeutic use.


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