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Abstract

FORMULATION AND EVALUATION OF ORAL MOUTH DISSOLVING FILM OF ANTIEMETICS DRUGS

Prashant More*, Sachinkumar Patil and Shitalkumar Patil

ABSTRACT

Fast dissolving oral films (FDOFS) are the most advanced form of oral solid dosage form due to more flexibility and comfort. It improve the effectiveness of dissolving film within minute in oral cavity after the contact with saliva as compared to fast dissolving film, without chewing and no need of water for administration. This is used in solid dispersion method with gum acacia at weight ratio of 1:4 showed excellent film forming characteristics such as disintegration time of 57 sec and percentage drug release 95.95% within 2 minutes. This study as formulation and evaluation the oral mouth dissolving film of Granisetron as used to treat in nausea, vomiting. The formulated by oral mouth dissolving film of Granisetron using suitable polymer like hydroxypropyl methyl cellulose (HPMC) and in combination with aspartame as sweetener sucrose, ascorbic acid as saliva stimulating agent, diethyl phthalate as plasticizer, and peppermint oil as a flavoring agent. The prepared films were evaluated in invitro drugs release.

Keywords: Fast dissolving films, oral mucosa, solid dispersion method.


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