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Abstract

ANTIOXIDANTS IN THE HEALING OF POST PERIODONTAL FLAP SURGERY- A POST-SURGICAL CLINICAL TRIAL

R.S. Senthil Rajan, Krishna Kripal*, Thaslim Fathima N., Aiswarya Dileep, Remya Nath K.

ABSTRACT

Introduction: Periodontitis is an inflammatory condition that results due to the loss of the critical balance between the virulence factors produced by microorganisms and the inflammatory host response. Antioxidants scavenge free radicals and prevent the damage caused by them. Ubiquinol (reduced form coenzyme Q10) serves as an endogenous antioxidant which increases the concentration of CoQ10 in the diseased gingiva and effectively suppresses advanced periodontal inflammation. Objective: This study aims to assess and compare clinically the wound healing after periodontal surgery in patients undergoing antioxidant therapy. Methodology: A total of 40 patients with chronic periodontitis who were required to undergo periodontal flap surgery between the age group of 25-45 years were enrolled for the study and grouped as follows: (i) Group I: (20 patients) antioxidant capsules were administered to the patients post periodontal flap surgery (twice daily for a week) and (ii) Group II: (20 patients) placebo capsules were administered to the patients post periodontal flap surgery. Wound healing was assessed on the 7th day using: Early wound index (Wachtel et al.), Wound evaluation scale, Wound Healing Index (Landry, Turnbull and Howley) and Visual analogue scale (VAS). Result and Conclusion: The scores of the indices showed significant reduction of gingival inflammation and pain along with better wound healing post periodontal flap surgery with the use of Coenzyme Q10 oral supplements. Antioxidants may have beneficial effects on functional mechanisms regulating fibroblast migration and proliferation during gingival healing and periodontal repair.

Keywords: Antioxidants, Coenzyme Q10, Periodontal flap surgery, Wound healing.


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