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Abstract

DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF β, β -DIPHENYL PROPIONIC ACID DERIVATIVES ON ALBINO WISTAR RATS FOR PHARMACEUTICAL INTERESTS

Punet Kumar*, Sangam and Vidhan Chand Bala

ABSTRACT

Phenyl propionic acid is as safer and more potent analgesic and inflammatory compound. The present scenario studies the synthesis of β, β--diphenyl propionic acid derivatives. β, β -diphenyl propionyl chloride (Intermediate compound) was prepared by the reaction of β,β- diphenyl propionic acid, and thionyl chloride. β, β-diphenylpropanoyl chloride was reacting to a number of aromatic amines in the presence of potassium carbonate in acetone. The synthesized compound is characterized by physical properties, IR, 1HNMR, Mass spectral data. Synthesis derivatives are examined to find out an analgesic activity (the method of working hot plates and tails Flik method) and anti -inflammatory activity (a method induced by Carrageenan induced edema) with Diclofenac and Indomethacin as standard drug. AK-3 (Morpholine derivative) and AK-5(diphenylamine derivative) are potent analgesics and anti-inflammatory compounds. The derivatives of Arylpropionic acid have pain relief and a great space for further development as a similar and anti-inflammatory agent.

Keywords: Aryl propionic acid derivatives, ?, ?-diphenyl propionyl chloride, inflammation, Albino rats, Diclofenac sodium, Analgesia, Eddy’s Hot Plate Method.


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