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Abstract

DEVELOPMENT AND CHARACTERIZATION OF OXICONAZOLE NITRATE LOADED ETHOSOMAL GEL FOR TREATING FUNGAL INFECTIONS

Wasim Ahmed Khan*, Vikas Sharma, Poonam Maurya and Rohit Kumar Bijauliya

ABSTRACT

The present investigation includes development and characterization of oxiconazole nitrate loaded ethosomal gel for treating contagious diseases. Topical therapy permits administration of small amount of oxiconazole nitrate, which is directly applied on to the skin such that it penetrates through the skin and reaches the specific site to show its pharmacological action efficiently as in this route of drug delivery first pass metabolism is bypassed and by this route of drug delivery and more than 70% bioavailability was achieved. Effect of different formulations on characterization and in-vitro drug release was conducted and ethosomes containing ethanol showed better entrapment efficiency, small vesicle size, high transdermal flux and maximum skin penetration. One basic and advantageous methodology is use of medications in plan with versatile vesicles or skin enhancers. Significant enhanced delivery of oxiconazole nitrate through transdermal route could be obtained by using vesicular drug carrier systems - Ethosomes. The present examination was meant to explore the capability of ethosomes in upgrade of oxiconazole nitrate transport over the skin, qualities of ethosomes and their in-vitro skin pervasion conduct. The present work also focuses on making the formulation more pharmaceutically acceptable.

Keywords: Ethosomes, Transdermal Drug Delivery, Oxiconazole Nitrate, Fungal Infections.


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