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Dhanashree Ravindra Deshpande* and Asokan V.


Introduction: Infertility is presently a leading and longstanding gynaecological issue affecting approximately 10-15% in Indian population, of which anovulation accounts for 40% of all its’ causes. The incidences of complications of ovulation inducing drugs of modern medicine are found widely. On the contrary, safer, holistic, yet fast acting rasaushadhi (herbo-mineral drugs) formulations are mentioned in Ayurveda. The present study, thus aimed at evaluating the ovulation inducing effect of Pushpadhanva rasa by comparing with modern drug, Clomiphene citrate. Methodology: The study was conducted among 30 female subjects, diagnosed of anovulation with either primary or secondary infertility, fulfilling the inclusion criteria, randomly allocated into two equal groups. Group A received Pushpadhanva rasa vati (250 mg twice a day with milk, honey and sugar before food, from 1st day of menses till 20th day), while Group B was administered with Tab. Clomiphene citrate (50mg OD, from day 2 of menses, for 5 days) for three menstrual cycles. The observations and results were assessed by follicular study conducted from 9th day of menstrual cycle till 20th day for three consecutive cycles. Results: Ovulation was observed in 40% of subjects in Group A and 53.3% of subjects in Group B. Discussion: Pushpadhanva rasa has ingredients which pacify vata, pitta and kapha dosha thereby resulting in normal functioning of H-P-O axis, beejotpatti (oogenesis) and beeejotsarga (ovulation). Conclusion: Though Pushpadhanva rasa showed comparatively less percentage of improvement, it proves to be effective due to absence of side effects like ovarian hyper-stimulation, multiple pregnancies.

Keywords: Vandhyatva, Anovulation, Infertility, Pushpadhanva rasa.

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