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Abstract

LIPID BASED NANOCARRIERS OF TAZAROTENE FOR THE TREATMENT OF PSORIASIS: OPTIMIZATION AND IN VITRO STUDIES

Mayurbhai P. Parmar*, Dr. L. D. Paterl, Bhoomita G. Hadia, Lalaji Rathod and Kinjal Parikh

ABSTRACT

The present investigation dealt with the formulation development, optimization, in vitro and in vivo study of tazarotene loaded nanocarriers for the treatment of psoriasis. The lipid based nanocarriers i.e. SLN and NLCs were prepared by melt emulsification-sonication. Process variables were optimized by one variance at time (OVAT) approach. Experimental design -Box Behnken design and Artificial Neural Network were used for optimization of various formulation parameters of Tazarotene loaded NLCs and SLNs. Various physicochemical parameters such as particle size, zeta potential, assay and % entrapment efficiency were measured. Further drug loaded SLNs and NLCs were loaded in Carbopol 980 gel. The gel was characterized for pH, viscosity, drug content uniformity, homogeneity, stability study and occlusion test. Drug loaded NLCs, SLNs with or without gel base was evaluated for invitro drug diffusion study, cellular uptake study, MTTassay, and cytotoxicity study using A431 skin cancer epithelial cell line. The particle size range of the optimized formulation was215.2 nm ± 4.5 nm with zeta potential -37.8 mV ± 3.4 mV, and entrapment efficiency was 57±3% for SLNswhile in case of NLCs, the particle size was around 235.22 nm ± 6.8 nm with zeta potential of -39.8 mV ± 3.7 mV, andentrapment efficiency of 60-65% for NLC. The cell viabilitystudy also indicated that formulation was non-toxic to cells. The cellular uptake study was done using confocal microscopy which indicated that the drug loaded SLNs and NLCs were taken up by the cells in peripheral region.

Keywords: NLC - nano lipid carrier; SLN – solid lipid nanoparticle, MTT - [3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]


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