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Abstract

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES 0F PIPER CHABA IN ALLOXAN INDUCED DIABETIC MICE

Md. Monirul Islam*, Md. Wasim Bari, Dil Afroza, Mst. Zenika Nasrin, Hasna Hena Laboni, Md. Abdul Jabbar, Sinthia and Mohammad Amirul Islam*

ABSTRACT

Diabetes mellitus (DM) is a systemic metabolic disorders with several major health complications affecting both the quality and the length of life. The purpose of this study is to appraise the antidiabetic and antihyperlipidemic activities of the Piper chaba plant extract. Diabetes was induced in overnight fasted mice by a single intraperitoneal injection of Alloxan (80 mg/kg body weight) in a 0.1 M sodium citrate buffer (pH 4.5). The animals were divided into five groups with five animals in each and treated with both the acetone and ethanol extract of P. chaba at dose 100 mg/kg and 200 mg/kg body weight respectively. The results showed that P. chaba plant extract decrease blood glucose level significantly (p<0.001 to p<0.01) and also regulated parameters of lipid profile levels (TG, TC, LDL, VLDL, and HDL) significantly (p<0.001 to p<0.01) in experimental model of diabetes mellitus. The levels of serum SGPT, SGOT and CRP were also adjusted to the normal level notably (p<0.001 to p<0.01) by the oral administration of P. chaba plant extract. The results obtained from this study indicate that the acetone and ethanol extract of P. chaba contains bioactive substances with hypoglycemic potency.

Keywords: Diabetes, antidiabetic, P. chaba, lipid profile.


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