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Abstract

EVALUATION OF PHYTOCHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITY OF THYMELAEA HIRSUTA (L.) ENDL, AND THAT UTILISED AS A CONVENTIONAL TREATMENT OF INFERTILITY AND DIABETIC IN LIBYA

Fouzy Alafid*, Salem Mohamed Edrah*, Fatimh Mustafa Meelad, Soad Belhaj, Khaled Altwair and Naser Ramdan Maizah

ABSTRACT

Thymelaea hirsuta (L.) Endl is used in Libya, as a folk medicine for the medication, firstly traditionally used to treat infertility, and secondly used for another disease's treatment such as diabetics. The results of qualitative phytochemical screening it is determined that the plant containing a rich amount of secondary phytoconstituents metabolites such as soluble starch, resin, balsam, flavonoids, tannins & phenols, diterpenes, triterpenes & sterols, saponins, alkaloids, polypeptides (proteins & amino acids), cardiac glycosides, carbohydrates, volatile oils, and fixed oils and fats were present in the plant extracts, while each of anthraquinones and phlobatanins were not present. Quantitive evaluation, the percentages yields of each of aqueous and ethanolic extracts were 89.3, 93.20 % respectively,while the percentages yields of each of flavonoids, saponins and alkaloids 35.23, 29.41, 39.72, 89.3, 93.20 % correspondingly. The effectiveness of aqueous and ethanolic extracts of the Thymelaea hirsuta (L.) Endl plants against the bacterial strains, where the crude plant extracts have good inhibitors against bacterial and it was among 8 to 12 mm. In addition, the aqueous and ethanolic extract has the highest inhibition zone 12 mm against Escherichia Coli, while each of Klebsiella pneumonia and Pseudomonas aeruginosa were 11 mm, though, 10 mm were from aqueous extract against each of Pseudomonas aeruginosa and Staphylococcus Epidermis, though 9 mm were from aqueous and ethanolic extracts against each of Klebsiella pneumonia and Staphylococcus Epidermis, and 8 mm were from aqueous and ethanolic extracts against each of Proteus vulgaris and Staphylococcus Aureus, respectively.

Keywords: Thymelaea hirsuta (L.) Endl, Secondary Phytoconstituents Metabolites, Quantitive Evaluation, Antibacterial, Infertility.


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