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Abstract

PROTECTIVE EFFECTS OF CACTUS AND/OR PAPAYA JUICES AGAINST HEPATIC AND TESTICULAR TOXICITY INDUCED BY CHLORPYRIFOS IN ALBINO RATS

Dr. Huda E. Mogahed*, Amira Abd El-Rhman, Nora M. El-Sheikh and Heba Barakat

ABSTRACT

This study aimed to evaluate the effect of cactus and/or papaya juices
on chlorpyrifos induced toxicity in ratʼs liver and testes. A total of
sixty albino rats weighing (180g -200g) were used for this study. Rats
were divided into 5 groups each of 12 rats. First group was left as
control group. Second group was given chlorpyrifos 6mg/kg b wt. The
other three groups were given cactus, papaya juices and both of them
as 20ml/kg b wt, subsequently along with chlorpyrifos dose. All doses
were orally administered daily for 28 successive days. At the end of
the experimental period, blood samples, liver and testes were collected
from each rat for biochemical analysis. Oral administration of
chlorpyrifos for 28 days in a dose of 6 mg/kg bwt, significantly
increased the percentage of DNA fragmentation, caspase-3 level in liver and testes tissues. A
significant increase in serum alanine aminotransferase, aspartate aminotransferase, catalase,
cytochrome P450, paraxonase-1 activity as well as tumor necrosis factor- α, malondialdehyde
and follicle stimulating hormones levels and decrease in testosterone and luteinizing hormone
levels was observed. On the other hand the administration of tested chlorpyrifos with juices,
reduce the percentage of DNA fragmentation, caspase-3 level and directed enzymes activity
and hormones levels toward normal. The effect on the liver is one of the main toxic effects of
this product. In conclusion cactus and papaya juices have beneficial effects as it tends to
dampen chlorpyrifos toxicity in rats.

Keywords: cactus, papaya, chlorpyrifos, testosterone, DNA fragmentation, paraxonase- 1.


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