Abstract

META-ANALYSIS: POOR GLYCEMIC CONTROL OF GLYCOSYLATED HEMOGLOBIN AND CARDIOVASCULAR DISEASE IN DIABETES MELLITUS

Ibrahim S. Alduraywish*, Shahad B. Sindi, Abdulrahman A. Habib, Muna A. Alnasser, Omnia A. Bahadi, Baraa K. Alsamman, Ali K. Muqri and Anoud A. Althagafi

ABSTRACT

Background & Purpose: Diabetes mellitus (DM) is strongly associated with an elevated chance for coronary heart disease (CHD) and cardiovascular disorder (CVD) which incorporates CHD, stroke, heart failure, myocardial infarction and peripheral arterial disorder or even mortality. The aim of this study is to offer cumulative information the impact of glycemic control of glycosylated hemoglobin on Cardiovascular sickness (CVS) in Diabetes Mellitus (DM) cases. Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify family medicine RCTs, clinical trials, and comparative studies, which studied the outcome of Poor Glycemic Control (GC) versus Good (GC) of diabeticpatients. A metaanalysis was done using fixed-effect method. The primary outcome was all-cause mortality. Secondary outcomes were Cardiovascular Disease (CVD) rate ―all events‖, Coronary Artery Disease (CAD) and Heart Failure (HF). Results: 9 studies were identified involving 405051 patients, 86316 in the Poor GC and 319005 in the Good GC. Regarding outcome measures, meta-analysis study showed that, highly significant increase in all-cause mortality, CVD rate, CAD rate and HF rate(p < 0.01 respectively), with risk ratio (RRs) of (2.07, 1.35, 2.56, 2.45 respectively). Conclusion: To conclude, diabetic patients with poor glycemic control are at high chance of cardiovascular comorbidities or even mortality.

Keywords: Poor Glycemic Control, Glycosylated Hemoglobin, CVS, DM.