META-ANALYSIS: POOR GLYCEMIC CONTROL OF GLYCOSYLATED HEMOGLOBIN AND CARDIOVASCULAR DISEASE IN DIABETES MELLITUS
Ibrahim S. Alduraywish*, Shahad B. Sindi, Abdulrahman A. Habib, Muna A. Alnasser, Omnia A. Bahadi, Baraa K. Alsamman, Ali K. Muqri and Anoud A. Althagafi
ABSTRACT
Background & Purpose: Diabetes mellitus (DM) is strongly
associated with an elevated chance for coronary heart disease (CHD)
and cardiovascular disorder (CVD) which incorporates CHD, stroke,
heart failure, myocardial infarction and peripheral arterial disorder or
even mortality. The aim of this study is to offer cumulative information
the impact of glycemic control of glycosylated hemoglobin on
Cardiovascular sickness (CVS) in Diabetes Mellitus (DM) cases.
Methods: A systematic search was performed of PubMed, Cochrane
library Ovid, Scopus & Google scholar to identify family medicine
RCTs, clinical trials, and comparative studies, which studied the
outcome of Poor Glycemic Control (GC) versus Good (GC) of diabeticpatients. A metaanalysis
was done using fixed-effect method. The primary outcome was all-cause mortality.
Secondary outcomes were Cardiovascular Disease (CVD) rate ―all events‖, Coronary Artery
Disease (CAD) and Heart Failure (HF). Results: 9 studies were identified involving 405051
patients, 86316 in the Poor GC and 319005 in the Good GC. Regarding outcome measures, meta-analysis study showed that, highly significant increase in all-cause mortality, CVD rate, CAD rate and HF rate(p < 0.01 respectively), with risk ratio (RRs) of (2.07, 1.35, 2.56, 2.45 respectively). Conclusion: To conclude, diabetic patients with poor glycemic control are at high chance of cardiovascular comorbidities or even mortality.
Keywords: Poor Glycemic Control, Glycosylated Hemoglobin, CVS, DM.
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