Abstract

AN EXPERIMENTAL STUDY TO EVALUATE THE EFFICACY OF GUDUCHYADI NIRUHA BASTI IN THE MANAGEMENT OF PARKINSONISM

Dr. Rohit Shrikant Kashikar*, Dr. Niranjan Rao and Sudhakar Bhat

ABSTRACT

Parkinsonism is typically considered a chronic progressive neurodegenerative movement disorder. In the recent times it was seen that Constipation is an early indicator and a common symptom which might be a possible cause for Parkinsonism. This disease is explained as syndrome comprising of various groups of disorders that can be attributed to Parkinsonism. One of the very important concepts quoted in Ayurveda is the Concept of avarana, where the gati, the unique feature of Vata is obstructed by Kapha dosha, thus leading to the disease. The best modality for such a disease condition explained by our Acharyas is the Basti chikitsa. Very few experimental studies have been taken up, on Basti karma to provide the data proving the efficacy of this clinically effective procedure. Hence to give preclinical support to the effectiveness of Guduchyadi niruha basti explained in the classics, this experimental study was selected. For this a battery of well-known Neuro-muscular tests were selected with main focus on the efficacy in test protocols supposed to be predictive for the efficacy in treatment of Parkinsonism namely, Rota rod apparatus, Oxotremorine Test, Anti-Reserpine Test, L-Dopa Potentiation Test. Significant reversal of symptoms was seen in this work. Therefore from the data harvested from animal experimentation, it can be concluded that there is definite activity of Guduchyadi Niruha Basti in the effective management of Parkinsonism.

Keywords: Parkinsonism, Guduchyadi Niruha Basti, Wister Albino Rats, Anti-parkinsonian activity.